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Both mechanisms converge via factor X into a common final pathway. The clotting factors are protein molecules. “Activation” mostly means proteolysis (cleavage of protein fragments) and, with the exception of fibrin, conversion into protein-hydrolyzing enzymes (proteases). Some activated factors require the presence of phospholipids (PL) and Ca2+ for their proteolytic activity.
This allows brief procedures to be carried out or to prepare the patient for inhalational anesthesia (intubation). Administration of the volatile anesthetic must then be titrated in such a manner as to counterbalance the waning effect of the injectable agent. |
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