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A membrane transporter actively accumulates iodide in thyroid cells; this is followed by oxidation to iodine, iodination of tyrosine residues in thyroglobulin, conjugation of two diiodotyrosine groups, and formation of T4 and T3 moieties. These reactions are catalyzed by thyroid peroxidase, which is localized in the apical border of the follicular cell membrane.
The probable cause of rheumatoid arthritis is a pathological reaction of the immune system. This malfunction can be promoted or triggered by various conditions, including genetic disposition, age–related wear and tear, hypothermia, and infection. |
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