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The emetic effect disappears with repeated use because a direct inhibition of the emetic center then predominates, which overrides the stimulation of area postrema chemoreceptors. Opioids elicit pupillary narrowing (miosis) by stimulating the parasympathetic portion (Edinger-Westphal nucleus) of the oculomotor nucleus.
Since follicle growth and estrogen production are correlated, hypophysis and hypothalamus can “monitor” the follicular phase of the ovarian cycle through their estrogen receptors. Within hours after ovulation, the tertiary follicle develops into the corpus luteum, which then also releases progesterone in response to LH.

 

Since they may cause mucosal damage, their use should be short-term.
Regulations specify, among other things, maximum dosage (permissible single dose, daily maximal dose, maximal amount per single prescription). Prescriptions need to be issued on special forms the completion of which is rigorously monitored.

 

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